EGFR is a receptor tyrosine kinase of the ErbB family

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summary for EGFR inhibitor :



The epidermal development factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family.EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Subsequent activation, phosphorylation of cytoplasmic substrates happens and a signaling cascade is initiated that drives quite a few mobile responses, including changes in gene expression, cytoskeletalrearrangement, anti-apoptosis and increased cell proliferation.

Regulatory components:transcription factor binding internet sites inside the EGFR gene promoter:p53 and other transcription elements